ANBR Review by Li Fangyuan & Ling Daishun's Team

Abstract: The team of Prof.
Fangyuan Li from the School of Pharmacy of Zhejiang University and the team of Prof.
Daishun Ling from Shanghai Jiaotong University jointly proposed that the effective detection of ion levels in the brain and the monitoring of their dynamic changes would be helpful for the diagnosis of neurodegenerative diseases
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This paper mainly introduces the important role of metal ions in cell membrane potential and intracellular physiological activities and its characteristics in the occurrence and development of neurodegenerative diseases.
The application prospect of its dynamic change monitoring method in the diagnosis of neurodegenerative diseases
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This review helps to better understand the role of metal ions in the occurrence and development of neurodegenerative diseases, and suggests that the development of ion level detection and monitoring of its dynamic changes has great potential in the diagnosis of neurodegenerative diseases
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Keywords: neurodegenerative diseases, ion level detection, diagnostics, nanosensors, small molecule fluorescent probes As the population ages, neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, etc.
The prevalence rate of ) is increasing year by year, which seriously affects the quality of life of patients and increases the social medical burden
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How to realize the early diagnosis and early intervention of neurodegenerative diseases has become a major problem that needs to be solved urgently
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It is well known that ions are closely related to various physiological activities of the human body, such as participating in the generation of cell membrane action potentials and various intracellular life activities
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Studies have shown that a variety of diseases are accompanied by ion disturbances in the process of development, especially in neurodegenerative diseases
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In recent years, the continuous development of ion detection methods in vitro and in vivo provides new ideas for the diagnosis of neurodegenerative diseases
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Based on this, Professor Li Fangyuan's team from Zhejiang University School of Pharmacy and Professor Ling Daishun's team from the Center for Transformative Molecular Frontier Science of Shanghai Jiao Tong University discussed the use of effective brain ion level detection and dynamic change monitoring methods to help diagnose neurodegenerative diseases
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The related results "Neurodegenerative Disease Diagnosis via Ion-Level Detection in the Brain" were published in Advanced NanoBiomed Research
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The first author of the review is Dr.
Chen Ying from the School of Pharmacy, Zhejiang University, and the corresponding authors are Prof.
Li Fangyuan and Prof.
Ling Daishun
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The important role of ion disorder in the occurrence and development of neurodegenerative diseases The collaborative team has designed and synthesized an ultra-sensitive K+ probe prepared by the self-assembly method of the ligand surface interface, which is the first time to achieve non-invasive in a free living organism.
real-time dynamic brain neural activity monitoring
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This work provides new ideas for the exploration of brain mysteries such as the mechanism of neurodegenerative diseases and the relationship between nerve impulses and behavior
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In this review, the close relationship between ion disturbance and various pathological features of neurodegenerative diseases is firstly introduced, such as K+, H+, Na+ and Cl− disturbances lead to abnormal action potentials of nerve cells; Fe2+/3+, Cu+/2 +, Mn2+/3+, Zn2+ and Ca2+ disturbances are associated with pathological protein production, oxidative stress, abnormal organelle function and imbalance of various enzyme activities
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This review mainly lists some representative and breakthrough ion level detection methods, including: 1) Ex-situ detection methods, such as the use of Raman scattering spectroscopy and X-ray fluorescence spectroscopy to detect ions in biological samples such as cerebrospinal fluid; 2) In situ detection methods, such as the use of small molecule fluorescent probes and nanosensors, etc.
, to realize the detection of ion levels in nerve cells and brain tissue and the monitoring of their dynamic changes
.

Based on the important role of ion disorders in the occurrence and development of neurodegenerative diseases, this review finally expounds the great application potential of ion level detection and dynamic change monitoring methods in the diagnosis of neurodegenerative diseases, including: 1) Using ion disorders and neurodegeneration It is expected to use ions as diagnostic markers to achieve early diagnosis of diseases; 2) Through the real-time dynamic monitoring of ions, it is expected that the mechanism of occurrence and development of neurodegenerative diseases can be deeply explored at the level of living animals; 3 ) At present, clinical symptoms are the main indicators for staging of neurodegenerative diseases, and ion level detection and monitoring of its dynamic changes are expected to achieve accurate staging of diseases from the molecular level
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Therefore, designing and synthesizing ion-specific probes with high sensitivity and selectivity to realize the detection of ion levels in the brain and the monitoring of their dynamic changes will help to deeply explore the pathogenesis of neurodegenerative diseases and promote the early diagnosis of diseases
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Application Prospects of Brain Ion Level Detection and Dynamic Change Monitoring in Neurodegenerative Diseases WILEY Paper Information: Neurodegenerative Disease Diagnosis via Ion-Level Detection in the BrainYing Chen, Min Wei, Jiyoung Lee, Jing Zhao, Peihua Lin, Qiyue Wang, Fangyuan Li*, Daishun Ling*Advanced NanoBiomed ResearchDOI: 10.
1002/anbr.
202100007Click "Read the original text" in the lower left corner to view the original text of the paper
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Introduction to Advanced NanoBiomed Research Journal Advanced NanoBiomed Research (ANBR) aims to provide a publishing platform for nanomedicine, bioengineering and biomaterial research to improve human health, focusing on the application of these fields in disease diagnosis and treatment, and expects to build an Advanced series in the field of biomedicine The flagship open access journal
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