An detoxifying enzyme is closely related to obesity

, a key enzyme involved in human metabolism, CYP2B, plays an important role in obesity and fatty liver disease, especially in the male population, in addition to its unique detoxification, according to scientists at Clemson University in the United States. The findings were published recently in the Journal of Nutritional Biochemistry.
a team led by Professor William Baldwin of the University, using a new mouse model developed by the lab to study the role of the CYP2B gene in obesity.
: "Our study shows that CYP2B plays an important role in the metabolism of unsaturated fatty acids, it has nothing to do with eating habits, and certain chemicals can inhibit CYP2B. We found that male mice that lacked the CYP2B gene were more obese than wild mice that also ate high-fat foods. The
suggests that the CYP2B gene may have some effects on human health. William Baldwin said: "If you are exposed to chemicals metabolized by CYP2B, or CYP2B gene inhibitors, it may mean that there are no significant metabolites in the body." Conversely, if you lack the CYP2B gene in your body, you may be more likely to retain white adipose tissue in your body, so you are more likely to be obese. In
, male mice without the CYP2B gene also had an increased incidence of fatty liver disease without eating high-fat foods.
William Baldwin said: "The CYP2B gene has to send a message telling fat to go to an area, which means that the gene has a dual role - metabolism of toxic substances and chemicals and drugs in the environment, but may also be involved in lipid metabolism, sending signals telling us how to distribute fat." Female
who lacked the CYP2B gene did not show a more significant obesity bias, although there were indications that they had higher rates of liver damage than wild female mice.
same time, gene expression is affected. The expression of the CYP2B gene in mice on the right diet was similar to that of wild mice on a high-fat diet. William Baldwin said: "When mice with CYP2B gene loss were fed regular food, their liver system reacted like eating high-fat foods. (Source: Yang Yan, China Science Journal)
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