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Amazing discovery: Alleles are different in paternal inheritance and maternal inheritance.

 Last Update: 2022-01-07
 Source: Internet
 Author: User

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dna methylation epigenetics

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The research team focused on the H19 gene locus.

"Although the general imprinting mechanism of the mouse H19 locus has been well established, it is not clear how the expression of H19 is affected by its own methylation status," explained Assistant Professor Hitomi Matsuzaki, who was responsible for this.

Then, the research team hypothesized that by reversing H19 ICR, thereby reversing its direction, they could reduce H19 methylation, and they created mutant mice to test this

"Our findings about maternal genetic alleles are quite unexpected, especially considering the father's data," said assistant professor Matsuzaki

Further studies did not provide evidence that the methylation status of ICR is related to differences in the expression of H19 in maternal alleles

In conclusion, Assistant Professor Matsuzaki and his colleagues provided convincing insights into the complex nature of mouse genome imprinting

Hitomi Matsuzaki, Yu Miyajima, Akiyoshi Fukamizu, Keiji Tanimoto.

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