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Reduced gait speed is a common feature of normal aging, but has also been associated with cognitive decline in subjects with subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and dementia
These studies have shown specific links, such as between stride length and the globus pallidus, or stride length and the prefrontal cortex
diagnosis
Combining information from gait and cognition may identify patients at high risk for dementia better than either measure alone
Alzheimer's disease (AD) is the most common cause of progressive cognitive impairment in older adults
In this longitudinal study with a 15-year follow-up, they investigated the risk of cognitive decline in community residents (n = 287) with reduced gait speed but intact cognitive function
The sample (n = 287) was from the Gothenburg H70 Birth Cohort Study, followed between 2000 and 2015
They found that participants with worsening CDR scores during follow-up had slower gait speeds on most exams
Subjects with pathological CSF Aβ1-42 concentrations at the 2009 examination had a greater reduction in gait speed compared with previous examinations
These results suggest that a decline in gait speed precedes cognitive decline , is associated with Alzheimer's pathology, and may be used for early detection of increased risk of dementia development
Decreased gait speed precedes cognitive decline
Slowing gait speed precedes cognitive decline by several years.
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