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Alzheimer's & Dementia: The relationship between cardiovascular risk burden and the risk of dementia and brain disease: a population-based cohort study

 Last Update: 2021-07-30
 Source: Internet
 Author: User

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Due to the aging of the world's population, the number of people affected by dementia is increasing.
This is one of the biggest challenges to health and social care in the 21st century
.

Since there is still no effective treatment for dementia, identifying the modifiable risk factors and promoting their prevention has always been a priority for public health authorities

prevention

Many studies have investigated the single heart vascular risk factors, including age, diabetes , high blood pressure, smoking and high cholesterol influence hyperlipidemia risk of dementia, but the results of these studies are not consistent
.

Given that these cardiovascular risk factors tend to gather and influence each other in individuals, it is best to use a multivariate risk prediction algorithm that includes these risk factors to study the overall impact of cardiovascular risk burden on dementia

Heart vascular diabetes cholesterol

The Framingham General Cardiovascular Risk Score (FGCRS) is a predictive algorithm that evaluates cardiovascular risk burden and cardiovascular disease (CVD) by combining demographics (ie age and gender) and traditional cardiovascular risk factors Risk
.

Several other studies have used different comprehensive scores (including FGCRS and dementia risk scores) that summarize vascular risk factors to predict the risk of dementia

The relationship between the combination of multiple vascular risk factors (such as FGCRS) and Alzheimer’s disease (AD) dementia risk remains uncertain .

After multiple attributions, among participants without dementia, the risk ratio between FGCRS level and dementia and 95% CI (n = 1588)

After multiple attribution, among participants without dementia, the hazard ratio between FGCRS level and dementia and 95% CI (n = 1588) After multiple attribution, among participants without dementia, between FGCRS level and dementia Hazard ratio and 95% CI (n = 1588)

The results showed that the multiple adjusted hazard ratios (HRs) (95% confidence interval [CIs]) of FGCRS for dementia were 1.
03 (1.
00-1.
07), and for Alzheimer's disease (AD) dementia it was 1.
04 (1.
01-1.
07)
.

In addition, higher FGCRS is associated with higher chronic cerebral infarction (probability [OR] 1.

Higher FGCRS and higher chronic cerebral infarction (probability [OR] 1.

Higher FGCRS is associated with increased risk of dementia and AD dementia Higher FGCRS is associated with increased risk of dementia and AD dementia

Original source:

Ruixue Song et al.

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