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The aging research community has successfully identified various risk factors for cognitive impairment in later life
People who are obese in middle age have a 2-3 times higher risk of developing dementia in old age than people who are not obese
Although BMI is associated with the risk of developing cognitive impairment and there is a subtle but sustained decrease in BMI with aging, limited evidence exists for simultaneous changes in BMI and cognitive decline, which better reflects both The natural process of health phenomena
To address this knowledge gap, Michal Schnaider Beeri of The Icahn School of Medicine at Mount Sinai et al.
They used longitudinal data from 15,977 older adults without dementia at the Alzheimer's Center, followed for an average of 5 years
They found that participants with a significant change in BMI (increase or decrease by ≥5%) or with a larger change in BMI experienced faster cognitive decline
This pattern was consistent regardless of whether baseline BMI was normal (BMI<25; N=5747), overweight (25≤BMI<30; N=6302), or obese (BMI≥30; N=3928)
CONCLUSIONS : Stability of BMI predicts better cognitive trajectories , suggesting the clinical value of tracking changes in BMI, which is easily measurable and may point to individuals who are experiencing cognitive decline
Stability of BMI predicts better cognitive trajectory
Stability in BMI over time is associated with a better cognitive trajectory in older adults.
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