Alzheimers Dementia: The greater the systolic blood pressure variation, the higher the risk of dementia

Dementia is the most common neurodegenerative disease in the elderly, leading to loss of functional independence and disability
.

Hypertension and other vascular risk factors are the main modifiable factors in the multifactorial etiology of dementia, but the relationship between blood pressure (BP) and dementia is still not fully understood

Blood vessels Therefore, conventional blood pressure levels may not be able to capture the subclinical changes of the many neural and hormonal feedback mechanisms involved in real-time blood pressure regulation

Nowadays, with the development of wearable devices, it has become feasible to measure blood pressure variability in a short period of time (for example, a few seconds)
.

Short-term blood pressure variability may capture subtle physiological changes in blood pressure regulation, which is different from chronic changes over many years, but its relationship with the risk of dementia is still unknown

Entropy, as a generally accepted method to measure the complexity of dynamic systems, provides a new method for quantifying the adaptability (ie complexity) of the ambulatory blood pressure process
.

Previous studies have linked the lower complexity of the dynamics of specific physiological signals (such as heart rate, standing posture) with aging and age-related adverse events (such as weakness and falls)

Each change in these mechanisms may affect the complexity and variability of blood pressure, which may contribute to the risk of dementia by impairing brain autoregulation, threatening cerebral blood flow, and causing cerebral ischemic damage
.

In addition, changes in blood pressure dynamics may also be caused by neurodegenerative processes in the brain's autonomic nerve control center

Yuan Ma and others of Harvard University used the Rotterdam study cohort to explore the high variability and low complexity of blood pressure dynamics related to the high risk of dementia
.

The follow-up is up to 20 years

This prospective cohort study followed 1835 elderly people from 1997 to 2016
.

In 2016, blood pressure complexity was quantified by sample entrophy, and blood pressure variability was quantified by coefficient of variation

They found that 334 participants developed dementia within 20 years
.

The reduced complexity of systolic blood pressure (SBP) is associated with a high risk of dementia

The reduced complexity of systolic blood pressure (SBP) is associated with a high risk of dementia

The important significance of this study is that it has discovered that lower complexity and higher inter-office variability between stroke-to-beat systolic blood pressure are potential new risk factors
.
This variability may be used as a predictor of dementia
.

Lower complexity and higher inter-office variability between stroke-to-beat systolic blood pressure are potential new risk factors
.
This variability may be used as a predictor of dementia
.
Lower complexity and higher inter-office variability between stroke-to-beat systolic blood pressure are potential new risk factors
.
This variability may be used as a predictor of dementia
.

Original Source: Ma Y, Zhou J, Kavousi M, Lipsitz LA, Mattace-Raso F, Westerhof BE, Wolters FJ, Wu JW, Manor B, Ikram MK, Goudsmit J, Hofman A, Ikram MA.
Lower complexity and higher variability in beat-to-beat systolic blood pressure are associated with elevated long-term risk of dementia: The Rotterdam Study.
Alzheimers Dement.
2021 Apr 15.
doi: 10.
1002/alz.
12288.
Epub ahead of print.
PMID: 33860609.

Ma Y, Zhou J, Kavousi M, Lipsitz LA, Mattace-Raso F, Westerhof BE, Wolters FJ, Wu JW, Manor B, Ikram MK, Goudsmit J, Hofman A, Ikram MA.
Lower complexity and higher variability in beat-to -beat systolic blood pressure are associated with elevated long-term risk of dementia: The Rotterdam Study.
Alzheimers Dement.
2021 Apr 15.
doi: 10.
1002/alz.
12288.
Epub ahead of print.
PMID: 33860609.
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