-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
White matter hyperintensity (WMH) often occurs in the elderly without cognitive impairment
.
They are related to vascular risk factors (VRF), such as hypertension or diabetes , and poor cognitive performance, especially executive function and processing speed
Vascular Diabetes
In Alzheimer's disease (AD) patients, WMH appears to be larger than the elderly with cognitive impairment, especially in the periventricular and posterior regions
.
These areas include the parieto-occipital and corpus callosum (splenium of the corpus callosum, S-CC)
AD and cerebrovascular diseases have a common VRF and often coexist
.
Cerebrovascular disease, such as WMH, is partly due to small vessel disease and is associated with an increased risk of clinical AD
However, little is known about the regional specificity of these associations, because most AD studies analyze global WMH volume or periventricular and deep WMH, but rarely analyze lobar WMH
.
This is especially important because the spatial distribution of WMH seems to be related to some different causes
diagnosis
The question is whether the number and spatial distribution of WMH in AD are different from age-related WMH, and whether WMH has a regional-specific effect on the cognition of Aβ-positive AD patients
.
In this way, Antoine Garnier-Crussard1 and others from the University of Normandy in France explored:
(1) Compare the Aβ negative control group (Aβneg-controls) matched with VRF to explore the regional distribution of WMH in Aβ-positive AD clinical syndrome patients (Aβpos-AD)
.
(2) Assess the specific relationship between regional WMH and cognitive performance, and investigate whether these relationships still exist after controlling the cortical amyloid burden, hippocampus and total gray matter volume
.
They estimated the WMH of 54 cognitively impaired amyloid β-positive AD (Aβpos-AD) and matched them with 40 cognitively barrier-free amyloid β-negative elderly controls (Aβneg-controls) for vascular risk factors
.
Under the control of brain amyloid burden, overall cortical atrophy and hippocampal atrophy, the cross-sectional relationship between regional WMH volume and cognitive ability in each group was evaluated
The WMH volume in all areas of Aβpos-AD patients is larger, and the corpus callosum compression (S-CC) has the largest change
The important significance of this study lies in the discovery: WMH is the main cause of cognitive decline in AD patients, and has nothing to do with amyloid deposition and atrophy
.
This study emphasizes the clinical significance of WMH in AD, especially the posterior WMH, the most obvious of which is the WMH of S-CC
WMH is the main cause of cognitive decline in AD patients and has nothing to do with amyloid deposition and atrophy.
WMH is the main cause of cognitive decline in AD patients and has nothing to do with amyloid deposition and atrophy.
Original source:
Garnier-Crussard A, Bougacha S, Wirth M, et al.
White matter hyperintensity topography in Alzheimer's disease and links to cognition.
Alzheimer's & Dementia.
Published online July 28, 2021:alz.
12410.
doi:10.
1002/alz.
12410Leave a message here
