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Alzheimer's & Dementia: Serum metabolome determines the risk of Alzheimer's disease

 Last Update: 2021-08-27
 Source: Internet
 Author: User

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Cognitive decline (CD) of the elderly is an issue of increasing concern.
It not only leads to a decrease in the overall quality of life and independence of the elderly worldwide, but also leads to an increase in the risk of dementia
.

Existing studies have shown that some life>provide promising strategic targets for early prevention

prevention

Two key life>exercise and diet
.

In fact, some clinical studies have documented the protective effects of increased exercise on CD/dementia, and revealed how more adherence to the Mediterranean diet can slow down CD and reduce the risk of dementia

Exercise and diet Exercise and diet Mediterranean diet Vitamin D

However, before we can effectively utilize the effects of exercise and incorporate protective bioactive compounds into targeted dietary interventions to reduce/prevent CD and potential dementia, a better understanding of neurobiology is needed Exercise and the role of these dietary regulators
.

Diet and exercise affect the risk of cognitive decline (CD) and dementia through endogenous factors triggered by the food metabolome and exercise .
These factors communicate with the brain through blood
.

These factors may act synergistically with hippocampal neurogenesis (HN) to change the risk of CD and dementia

Diet and exercise affect the risk of cognitive decline (CD) and dementia through endogenous factors triggered by food metabolome and exercise Diet and exercise affect cognitive decline (CD) and dementia through endogenous factors triggered by food metabolome and exercise the risk of these factors may generate synergies with hippocampal (HN), changing the CD and the risk of dementia

Population, research design, and cell trials

Population, research design, and cell test population, research design, and cell test

Recently, researchers used an in vitro neurogenesis test to study the effect of serum samples from a longitudinal cohort (n = 418) on hippocampal neurogenesis readings, and their relationship with future development of CD and dementia, over a period of 12 years
.

The results of the study showed that changes in apoptosis and the reduction of hippocampal progenitor cell integrity are related to exercise and diet, and can predict the subsequent risk of CD and dementia
.

In addition, the effects of exercise and diet on CD are specifically mediated by apoptosis

The changes in apoptosis and the reduction of hippocampal progenitor cell integrity are related to exercise and diet, and can predict the subsequent changes in CD and dementia risk .

Changes in hippocampal neurogenesis may mark the beginning of the pathological process and may become a biomarker of CD and dementia .

Original source:

Andrea Du Preez et al.

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