Alzheimer's Dementia: People with brain trauma have a higher risk of dementia

The complex interaction between the history of brain trauma and neurodegenerative diseases is an active field of study, and great progress has been made in recent years.
theory is that TBI may promote or mitigate cognitive decline in aging, which in turn may lead some people to develop dementia syndrome early.
interestingly, cognitive and other neuropsychiast symptoms (NPS), such as poor attention, dysfunction, and apathy, may persist long after TBI, similar to other symptoms of dementia syndrome.
Based on a study by the National Alzheimer's Coordination Center Unified Data Set (NACC-UDS), TBI history has been shown to be associated with clinicians misdiagnosing Alzheimer's disease (an increase in false positives assessed using gold standard autopsy neuropathology).
although the relationship between (1) TBI and dementia and (2) the link between NPS and cognitive decline in dementia has been extensively investigated, little research has been conducted on the effects of TBI on NPS during the development of dementia.
the NPS that occurs after TBI is often short-lived, however, in some populations the symptoms persist and lead to a significant decline in quality of life, unrelated to the associated onset of dementia.
NPS represents an important component of dementia syndrome pattern recognition and treatment, given that 97% of people with dementia are at some point in their course of life, NPS is associated with cognitive decline.
, there is little research, but limited data suggest that TBI history can influence the performance of NPS in dementia.
, for example, in all-cause dementia, a study found that those with a history of TBI showed an increased risk of inhibition disorders compared to those with no TBI history.
in Parkinson's disease, another study found that patients with a history of TBI reported an increased risk of depression during the course of their illness.
, Michael J.C Bray of Johns Hopkins University and others studied the link between TBI, NPS and cognitive decline in all-cause dementia based on NACC-UDS.
, the difference between the incidence of NPS and the onset of NPS compared to the diagnosis of dementia between participants with and without a history of TBI developed from normal cognition to allogeneic dementia.
They examined the occurrence of NPS on cognitively normal participants and counted the occurrence of NPS among cognitively normal participants, who developed all-cause dementia (n s 130) or non-existent (n s 849) depending on whether they had a history of TBI.
the rate of NPS in 8-year follow-up through survival analysis.
showed an increase in the prevalence and prevalence of apathy among participants with a history of TBI (44.7% vs. 29.9%, P s .0018), as well as a higher prevalence of movement disorders.
(17.2% vs 9.5%,P = .0458)。
addition, earlier anxiety disorders were associated with TBI (692 days before dementia diagnosis vs 161 days, P=.0265).
the significance of this study, it was found that the history of TBI was associated with an increased risk of NPS and an advance in the onset of the disease during the development of dementia.
original link: Bray, M. J., Richey, L. N., Bryant, B.R., Krieg, A., Jahed, S., Tobosky, W., ... & Peters, M. E. (2021). Traumatic brain injury alters neuropsychiatric symptomatology in all‐cause dementia. _Alzheimer's & Dementia_. Freeman Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medical and are not reproduced by any media, website or individual without authorization, and are authorized to be reproduced with the words "Source: Mets Medicine".
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