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Alzheimers Dementia: New discovery of neurofilament light chain: Differentiate between mental illness and dementia

 Last Update: 2022-03-05
 Source: Internet
 Author: User

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Despite significant advances in clinical neuroscience, many patients with cognitive and neuropsychiatric symptoms still face years of multiple evaluations, diagnostic uncertainty and delays, misdiagnosis, and imprecise management and prognosis in a major diagnostic odyssey, There are significant negative impacts on patients, families and the healthcare system

Behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) are clinically diagnosed with significant error rates

A biomarker that can help differentiate neurodegenerative and psychiatric disorders will have a major impact on patient care and assessment, as well as outcomes

Therefore, dDhamidhu Eratn et al.

This study, part of the Neuropsychiatric Disorders Study (MiND Study), was designed to expand on our earlier pilot work in a large, diverse cohort presenting with cognitive and neuropsychiatric symptoms, where the differential diagnosis included psychosis and neurological/neurodegeneration sexually transmitted diseases

Secondary objectives included assessing the diagnostic utility of NfL and t-tau in differentiating ND, PSY, CJD/RapidND groups, and specific diagnoses within these groups

They found that NfL was elevated in ND compared with PSY and controls, with the highest levels in CJD and RapidND

Compared with PSY and controls, NfL was elevated in ND, with the highest levels in CJD and RapidND

The significance of this study is that it demonstrates that the diagnostic utility of CSF NfL in differentiating ND from psychiatric disorders has strong generalizability and high accuracy

Diagnostic utility of CSF NfL in distinguishing ND from psychiatric disorders with strong generalizability

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