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Elevated systolic blood pressure (SBP), especially in middle age, increases the risk of dementia
The point of contention is:
- Increased blood pressure contributes to the amount of amyloid beta (Aβ) deposited in the brain;
- Higher blood pressure is a risk factor for cerebrovascular disease, which then leads to Aβ and phosphorylated tau (pTau) deposition and neurodegeneration and dementia
Participants with or without antihypertensive medication (AHM) confounded many studies on hypertension, cerebrovascular disease, and dementia risk
Trials of antihypertensive drugs had little effect on reducing the incidence of dementia
The University of Pittsburgh's Lewis H.
In GEMS, they assessed the association of SBP measured between 2000 and 2006 with dementia risk and brain biomarkers in 2009-2020 (n = 177), with a mean age of 95 years in 2020
They found that by 2020, only 9 (5%) of 177 patients were alive and cognitively impaired (CU)
The amount of Aβ is directly related to the level of SBP
Apart from Aβ, SBP emerged as an important predictor of dementia
The significance of the study was its finding that low SBP without antihypertensive medication was associated with a significantly lower risk of dementia and less Aβ
Low SBP without antihypertensive medication was associated with a significantly lower risk of dementia and less Aβ
ow untreated systolic blood pressure over 18 years is associated with survival free of dementia age 90+.
Alzheimer's & Dementia.
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