Alzheimer's dementia: Longitudinal changes in Alzheimer's disease biomarkers differ between cognitively normal blacks and whites

Alzheimer's disease (AD) is an irreversible neurodegenerative disease that affects approximately 6 million Americans, and the number of cases is expected to more than double by 2050
.

Solutions to this public crisis require prevention and/or treatment options that are effective for all, including underrepresented groups

Alzheimer's disease (AD) is an irreversible neurodegenerative disease that affects approximately 6 million Americans, and the number of cases is expected to more than double by 2050

Almost all of these important findings were based on predominantly white populations, and racial differences in AD biomarkers have rarely been studied

Alzheimer's disease (AD) biomarkers including cerebrospinal fluid (CSF) markers, amyloid uptake by positron emission tomography (PET), structural changes and cognition by magnetic resonance imaging (MRI), and their current longitudinal changes No comparisons have been made between blacks and whites

Chengjie Xiong et al.

A total of 179 blacks and 1180 whites in the study were cognitively normal at baseline and had longitudinal data from at least one biomarker pattern, and the team analyzed their annual rate of change
.

A total of 179 blacks and 1180 whites in the study were cognitively normal at baseline and had longitudinal data from at least one biomarker pattern, and the team analyzed their annual rate of change
.

Differences in estimated annual rates of change in biomarkers between blacks and whites

Differences in estimated annual rates of change in biomarkers between blacks and whites

Blacks had slower decline in CSF β amyloid (Aβ)42/Aβ40 than whites (P = 0.
0390) and slower amyloid (PET) accumulation (P = 0.
0157)
.

Blacks had slower decline in CSF β amyloid (Aβ)42/Aβ40 than whites (P = 0.
0390) and slower amyloid (PET) accumulation (P = 0.
0157)
.

Blacks had slower decline in CSF β amyloid (Aβ)42/Aβ40 than whites (P = 0.

Model Fit Plot of Longitudinal Trajectories of Biomarkers

Model Fit Plot of Longitudinal Trajectories of Biomarkers

CSF Aβ42 varied in opposite directions over time between blacks and whites (P = 0.
0039)
.

The annual increase in total tau and phosphorylated tau181 in black CSF was approximately half that in whites

CSF A CSF A β42 varied in opposite directions over time between blacks and whites (P = 0.

In conclusion, the team observed longitudinal ethnic differences in amyloid biomarkers

original source

Xiong, Chengjie et al.

Xiong, Chengjie et al.
“Racial differences in longitudinal Alzheimer's disease biomarkers among cognitively normal adults.
”  Alzheimer's & dementia: the journal of the Alzheimer's Association , 10.
1002/alz.
12608.
25 Feb.
2022, doi:10.
1002/alz.
12608 Xiong , Chengjie et al.
"Racial differences in longitudinal Alzheimer's disease biomarkers among cognitively normal adults.
"  Alzheimer's & dementia : the journal of the Alzheimer's Association commented here