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Alzheimers Dementia: Cerebrospinal fluid marker that predicts long-term neuropsychiatric symptoms

 Last Update: 2022-04-22
 Source: Internet
 Author: User

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Neuropsychiatric symptoms (NPS) are common in patients with dementia due to Alzheimer's disease (AD), but also in mild cognitive impairment (MCI)

However, the relationship between AD pathophysiology and NPS remains unclear, especially in older adults without dementia

A growing number of studies have examined the relationship between NPS and neuroimaging or plasma biomarkers of AD

In addition, in a large sample of community-dwelling dementia-free older adults, there were significant differences in responses to several CSF biomarkers of AD (i.

Hereby, Janina Krell-Roesch et al.

Core hypothesis: Higher neuropathological burden, as indicated by lower CSF Aβ42 levels, higher t-tau and p-tau 181 levels, and higher t-tau/Aβ42 and p-tau/Aβ42 ratios, is associated with High neuropsychiatric burden, i.

They included 784 individuals aged ≥50 years (699 with cognitive impairment, 85 with mild cognitive impairment) who received CSF amyloid beta (Aβ42), hyperphosphorylated tau181 (p- tau) and total tau (t-tau) and NPS assessment using Baker Depression and Anxiety Inventory (BDI-II, BAI) and Neuropsychiatric Inventory Questionnaire (NPI-Q)

They found: lower CSF Aβ42, higher t-tau/Aβ42 and p-tau/Aβ42 ratios with BDI-II and BAI total scores, clinical depression (BDI-II ≥ 13) and clinical anxiety (BAI ≥ 10) and anxiety and apathy assessed by NPI-Q

Lower CSF Aβ42, higher t-tau/Aβ42 and p-tau/Aβ42 ratios were associated with BDI-II and BAI total scores, clinical depression (BDI-II≥13) and clinical anxiety (BAI≥10) and NPI- Q-assessed anxiety and apathy

CSF Aβ42, t-tau/Aβ42 and p-tau/Aβ42 ratios are associated with NPS in community residents without dementia

Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of AgingLeave

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