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Currently, dementia is still a global challenge for health and social care due to the lack of effective medical treatments
.
Therefore, primary prevention through modifiable risk factors is a top priority to reduce the incidence of cognitive impairment and dementia
Prevention of heart blood vessels
The "Life Simple 7" (LS7) proposed by the American Heart Association (AHA) for primary prevention of cardiovascular disease comprehensively defines ideal cardiovascular health as the existence of four healthy behaviors (medium level of physical activity ≥150) Minutes/week, or vigorous level ≥75 minutes/week, or moderate and vigorous level ≥150 minutes/week, no smoking, body mass index [BMI]<25.
0, and healthy eating habits, including at least four of the following items: Fruits And vegetables ≥ 4.
5 servings/day, sodium <1500 mg/day, fish ≥ two servings 3.
5 ounces/week, whole grains ≥ 3 servings/day, sugary drinks <36 ounces/week), and three biological indicators ( Untreated total cholesterol <200 mg/dL, fasting blood glucose <100 mg/dL, untreated blood pressure <120/<80mmHg)
.
New evidence shows that LS7 is inversely proportional to the risk of dementia and Alzheimer's disease (AD)
.
However, there are also reports that the relationship between LS7 and cognition 16 and dementia is not significant
At present, only a few studies have investigated the association between adherence to a healthy life>
.
Currently, no studies have examined the impact modification of APOE ε4 carriers on the association between LS7 score and dementia risk
No studies have examined the effect of APOE ε4 carriers on the modification of the association between the LS7 score and the risk of dementia
They used the Cox model to study the relationship between the LS7 score and the onset of dementia
.
It was found that among the 1987 subjects, 291 patients with dementia were found during a median follow-up of 5.
In non-carriers of the lipoprotein E genotype ε4 (APOE ε4) allele, these associations also exist , but they are meaningless in carriers
.
The important significance of this study lies in the discovery that a higher LS7 score has a protective effect on dementia, especially in APOE ε4 non-carriers
.
.
A higher LS7 score has a protective effect on dementia, especially in APOE ε4 non-carriers
Guo J, Brickman AM, Manly JJ, Reitz C, Schupf N, Mayeux RP, Gu Y.
Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype.
Alzheimers Dement.
2021 May 2.
doi: 10.
1002/alz .
12359.
Epub ahead of print.
PMID: 33938146.
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