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Alzheimers Dement: Is plasma neurofilament light chain a predictive biomarker for Alzheimer's disease?

 Last Update: 2021-08-04
 Source: Internet
 Author: User

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exam light

neurofilament light

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Although cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers may become the ultimate diagnostic tool for the detection of Alzheimer’s disease (AD) , there is still an urgent need for a cost-effective, non-invasive, A multi-level approach to determine who should or should not accept these expensive and more invasive operations
.

diagnosis

Neurofilament light chain (NfL)is an interesting neurodegenerative biomarker in recent years.
It is a cytoskeletal protein expressed on large-caliber myelinated axons, which can be released into the extracellular fluid when axons are injured.
In
.

However, there is no large-scale characterization of NfL in different populations

Neurofilament Light Chain (NfL)Neurofilament Light Chain (NfL)

In a recent study published in "Alzheimers Dement" , researchers analyzed 890 Mexican Americans and 913 non-Hispanic whites from the Multi-Ethnic Health and Aging Brain (HABLE) Study of Latino Elderly People.
Baseline data was analyzed, including plasma NfL levels
.

"Alzheimers Dement"

Plasma NfL levels in subjects with different cognitive function states

In the unadjusted model, NfL was significantly related to age (p<0.
001), hypertension (p<0.
001), dyslipidemia (p=0.
02), and diabetes (p<0.
001)
.

With the change of age and gender, NfL is related to neurodegeneration (p<0.

NfL is significantly related to age (p<0.

Original source:

O'Bryant Sid,Petersen Melissa,Hall James et al.

Characterizing plasma NfL in a community-dwelling multi-ethnic cohort: Results from the HABLE study in this message

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