Alzheimer's and Dementia: The relationship between baseline amyloid proteins and neurofiber tau deposition in β-age Down syndrome (NiAD).

The diagnosis of Alzheimer's disease (AD) depends on the appearance of amyloid β (A beta) plaques and tau-containing nerve fiber tangles during autopsies.
recently, the emergence of positive electron emission fault scanning (PET) ligations for A beta and tau, such as piB3, and AV-14514, allows us to examine the relationship between cognition and AD pathophysiology in the body.
these studies have shown that tau pathology is more closely related to cognitive decline than A beta2 and is associated with AD diagnosis, amyloid-positive, and cognitive function.
adults with Down syndrome (DS) are consistently affected by AD-related pathology, characterized by the development of A-beta plaques in their fourth decade, and they show an increased prevalence of AD.
From a large amount of data, the overprodomy of amyloid preloom protein (APP) is due in part to chromosome 21 encoding the triple of APP, apparently associated with the high risk of AD in DS and the emergence of clinical AD esoploids at an earlier age.
recently, researchers published a study in Alzheimer's and Dementia aimed at evaluating the presence of tau in the brains of DS patients using the AV-1451 positive electron emission fault scan (PET) and the relationship between brain tau in Pittsburgh compound B (PiB)-PET.
study is a multi-center queue study.
participants included samples of DS patients recruited from the community and their sibling control groups.
exclusion criteria include magnetic resonance imaging (MRI) disorders and/or medical or psychiatric conditions that impair cognitive function.
researchers used multiple linear regression models (adjusted by age, sex, and between the manifestation sites) to assess the association between the study area's standard ingestion ratio (SUVR) (based on regions associated with Braak phase 1-6) and the whole brain's (11C) PiB SUVR (as a continuous and disaggregated variable).
the cohort study studied 156 participants (average age: 39.05 years, SD (8.4)).
results revealed a significant relationship between A-beta and tau pathology in DS patients.
as a two-part variable, the AV-1451 remains higher in each Braak region of the PiB (plus) participants.
the researchers also found that, according to their statistical model, the deposition of the AV-1451 SUVR accelerated, starting with the Area of Interest (ROI) of Braak 3, and the increase of the PiB SUVR.