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Alzheimer Dementia: What factors affect the amyloid markers in the blood?

 Last Update: 2021-10-09
 Source: Internet
 Author: User

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In 2018, the National Institute of Aging and the Alzheimer's Association (NIA-AA) research framework proposed the AT(N) system as the biological definition of Alzheimer's (AD), based on amyloid (A) The pathological process of phosphorylated tau (T) and neurodegeneration (N)

Given the invasive nature of obtaining CSF and the time and cost associated with neuroimaging, identifying biomarkers that are easier to obtain is an important goal

Blood biomarkers for AD and other dementias are very suitable for screening or diagnosis in the population , as well as for continuous evaluation to track disease progression

Screening diagnosis

This is especially important for establishing the reference range

It is important to understand whether levels vary with age and gender, or whether conditions such as chronic kidney disease (CKD) that can affect protein clearance should be considered

They analyzed the plasma markers (Aβ42, Aβ40, NfL, T-tau, Aβ42/40 ratio of 996 Mayo Clinic Aging Study (MCSA) participants aged 51 to 95 years on the Quanterix Simoa HD-1 analyzer ) To take a measurement

They found that in the cognitively impaired (CU), all plasma markers were age-related

For example, a higher Charlson comorbidity index and chronic kidney disease are associated with higher levels of all biomarkers

The important significance of this study is to illustrate; multiple variables affect the plasma biomarkers of amyloid pathology and neurodegeneration in the general population

Several variables influence the plasma biomarkers of amyloid pathology and neurodegeneration in CU in the general population

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