Alzheimer Dementia: Ruijin Hospital newly discovered patients with dementia, what is the cancer risk?

With the demographic trend of more and more elderly living in society, the spectrum of diseases in the population is changing, and non-communicable diseases affect more people than infectious diseases
.
In recent decades, neurodegenerative diseases, cancer, heart blood vessel disease and stroke (or cerebrovascular disease) is a major threat to the elderly

Unfortunately, there are currently not enough effective therapies to treat AD patients, and the progression of the disease is currently irreversible
.
There are many hypotheses related to AD pathology and pathophysiology.

Cancer, or tumor, is the second leading cause of death in the world
.
Cancer is a typical proliferative disease

Since both AD and cancer often occur in the elderly, it seems natural to seek a potential link between AD and cancer risk
.
As we all know, immune system dysfunction plays an important role in the pathogenesis of cancer, and immune cells will destroy cancer cells in the early stages

In addition, there seems to be a mysterious interaction between brain function and intestinal function, especially in pathological conditions
.
The trend of the microbiota-gut-brain axis has attracted the attention of researchers to neurodegenerative diseases

In this way, the Chen Shengdi team of Ruijin Hospital : explored the potential association between AD and cancer risk with or without diabetes, and further clarified this association pattern in the Chinese population
.
In addition, this study provides a solid foundation for future research on the common and mutually exclusive mechanisms of AD and cancer

Among 8097 AD patients, the HR for all subsequent cancers was 0.
822 (95% CI, 0.
728-0.
928; P=0.
002)
.
Among them, three specific cancers are related to AD: lung cancer (HR, 0.

The important significance of this study lies in the discovery: AD patients may have a lower chance of developing several cancers, including lung cancer, prostate cancer, and testicular cancer
.
At the same time, a positive correlation was observed between AD and a higher incidence of lymphoma
.

Original source:
Ren R, Huang Q, Xu G, et al.
Association between Alzheimer's disease and risk of cancer: A retrospective cohort study in Shanghai, China.
Alzheimer's Dementia.
Published online September 5, 2021:alz.
12436.
doi:10.
1002 /alz.
12436