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The worldwide incidence of Alzheimer's disease (AD) and other dementias is expected to reach approximately 135 million people in 2050
.
Long-term strategies to reduce clinical manifestations by preventing the transition from asymptomatic to symptomatic pathology have been adapted to AD
.
Periodontitis is considered a new risk factor for AD, although the confusing information about this relationship has rarely been simulated in human studies
.
In fact, periodontitis and AD have common risk factors, including age, obesity, diabetes , smoking, education and drinking, and possibly depression and nutrition
.
Diabetes affects 11% of the world's population, and treatment can be partly performed by dental assistants
In this Quasi-experimental design, they analyzed 177 periodontal treated patients from the "Greifswald Individualized Treatment Method" cohort and 409 untreated subjects from SHIP-TREND
.
The subjects were younger than 60 years old at the time of MRI examination, and the median observation period was 7.
3 years
Imaging markers of brain atrophy and brain aging in advanced AD were taken as the result
Periodontal therapy has a significant impact on AD-related brain atrophy Periodontal therapy has a significant impact on AD-related brain atrophy
The important significance of this research lies in the discovery: periodontitis is related to preclinical AD
.
Original source:
Schwahn C, Frenzel S, Holtfreter B, Van der Auwera S, Pink C, Bülow R, Friedrich N, Völzke H, Biffar R, Kocher T, Grabe HJ; Alzheimer's Disease Neuroimaging Initiative.
Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach.
Alzheimers Dement.
2021 May 29.
doi: 10.
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