Alzheimer & Dementia: Indifferent people are not only more prone to dementia, their brain structures are very different!

Neuropsychiatric symptoms (NPS) are very common in the cognitive function spectrum of the elderly.
In the development of cognitive ability, it affects half of patients with mild cognitive impairment and almost all patients with dementia
.

Neuropsychiatric symptoms have predictive value in predicting accelerated disease progression and functional decline

Neuropsychiatric symptoms have predictive value in predicting accelerated disease progression and functional decline

Apathy, defined as decreased motivation and goal-oriented behavior, is the most common neuropsychiatric symptom in the subtype of dementia, apathy, defined as decreased motivation and goal-oriented behavior, is the most common neuropsychiatric symptom in the subtype of dementia.

According to reports, up to 72% of Alzheimer's (AD) patients are indifferent
.

At the same time, apathy is a common and disabling feature of frontotemporal dementia (FTD).

Up to 72% of Alzheimer's (AD) patients have apathy.

In older adults with normal cognition, apathy increases the risk of dementia

Recently, a study led by a team from the University of Cambridge in the United Kingdom and published in the journal Alzheimer & Dementia conducted a comprehensive analysis of whether apathy can predict changes in the cognitive function of asymptomatic FTD patients
.

The researchers included asymptomatic carriers of MAPT, GRN, or C9orf72 mutations (N = 304) and relatives without mutations (N = 296) who underwent clinical evaluation and MRI at baseline, and were examined annually for 2 years
.

The latent growth curve model is used to analyze the longitudinal changes and their relationships of apathy, cognition, and brain gray matter volume

Changes in the indifference scores of asymptomatic carriers (red) and non-carriers (blue) within 2 years
.

Changes in the indifference scores of asymptomatic carriers (red) and non-carriers (blue) within 2 years
.

The results showed that in asymptomatic carriers, the severity of apathy increased over time, but not in non-carriers
.

Among asymptomatic carriers, baseline apathy predicts a decline in cognitive ability after two years, but not vice versa

In asymptomatic carriers, baseline apathy predicts a decline in cognitive abilities after two years.

The model only identified a significant decline in asymptomatic carriers (EST = -0.

The impact of baseline indifference on the annual rate of change ("slope") of Digit Symbol's test performance
.

The impact of baseline indifference on the annual rate of change ("slope") of Digit Symbol's test performance
.

In summary, apathy is an early sign of FTD-related changes and can predict subsequent subclinical deterioration of cognitive ability before the onset of dementia
.
Indifference may be a modifiable factor in FTD high-risk groups
.

In summary, apathy is an early sign of FTD-related changes and can predict subsequent subclinical deterioration of cognitive ability before the onset of dementia
.
Indifference may be a modifiable factor in FTD high-risk groups
.
In summary, apathy is an early sign of FTD-related changes and can predict subsequent subclinical deterioration of cognitive ability before the onset of dementia
.
Indifference may be a modifiable factor in FTD high-risk groups
.

 

references:

Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.
Alzheimers Dement.
2021 Jun;17(6):969-983.
doi: 10.
1002/alz.
12252.

Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.
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