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Dementia is one of the main causes of disability, affecting approximately 50 million people worldwide
.
It is well known that genetic and life>
The ε4 allele of lipoprotein E gene (APOE) is the genetic risk factor that has the greatest impact on late-onset Alzheimer's disease (AD), and it has also been identified as a risk factor for other subtypes of dementia
Although genotype is currently unchangeable, a recent study shows that the risks associated with genotype can be offset by following a favorable life>
.
.
Since there is no treatment for dementia, it is very important to find and solve the changeable life>can delay or prevent the occurrence of dementia
.
One potentially modifiable risk factor is sleep
.
Waking up too early, having difficulty falling asleep or staying asleep, and sleeping too long at night or during the day are common, and is attracting more and more attention in the crowd
A recent meta-analysis showed that there is a U-shaped relationship between sleep time and the occurrence of dementia, and people who sleep 7 hours a night have the lowest risk
.
The evidence regarding insomnia is more inconsistent.
In fact, most of the evidence on the relationship between sleep disorders and dementia comes from cross-sectional studies or studies with a follow-up period of less than 10 years
.
Given that the neurodegenerative changes that may lead to sleep disorders may occur decades before the onset of dementia, long-term longitudinal data are lacking
Another limitation of the current evidence is that most studies have studied participants over middle age (>65 years of age) and found that the relationship between sleep disturbance and dementia may be due to early changes related to the progression of dementia
.
In addition, the role of APOE in the relationship between sleep and dementia needs to be considered, because the APOE ε4 allele is related to both dementia and sleep disorders
The interaction of APOE status and sleep on the risk of dementia is reasonable, but few studies have investigated possible interaction effects
.
These studies have found inconsistent results and are limited to samples from older people, short follow-ups, and gender-specific samples
In this way, dEleni Palpatzis and others of UCL in the United Kingdom used data from UK Biobank to explore the relationship between APOE and sleep and dementia in middle-aged participants
.
First, they explored whether short and long sleep periods, insomnia, and excessive daytime naps are associated with an increased risk of all-cause dementia
.
Secondly, we studied whether APOE status will change sleep time and dementia; insomnia and dementia; and the relationship between daytime nap and dementia
They used Cox regression analysis to explore the relationship between sleep time, insomnia, and daytime naps and the occurrence of all-cause dementia among 397,777 middle-aged people, and their interaction with the genetic risk of APOE
.
During the median follow-up period of 10.
8 years, more or less than 7 hours of sleep was associated with a higher risk of dementia, as were daytime naps (HR: 1.
67; 95 % CI 1.
37-2.
03)
.
8 years, more or less than 7 hours of sleep was associated with a higher risk of dementia.
Stratified analysis showed that the effects of sleep disorders were similar in all APOE genetic risk groups
.
The important significance of this study lies in the discovery: short and long sleep time and daytime naps in middle-aged people are related to the occurrence of dementia in later life
.
Regardless of the genetic risk of the APOE genotype, sleep duration and quality are important to everyone
.
Original source:
Palpatzis E, Bass N, Jones R, Mukadam N.
Longitudinal association of apolipoprotein E and sleep with incident dementia .
Alzheimer's & Dementia.
Published online September 3, 2021:alz.
12439.
doi:10.
1002/alz.
12439
Longitudinal association of apolipoprotein E and sleep with incident dementia leave a message here
