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Alzheimer Dementia: Characterization of the Effects of Sample Processing on Alzheimer's Disease-Related Blood Biomarkers

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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Blood-based biomarkers for Alzheimer's disease (AD) have the potential to be implemented as a non-invasive screening tool

The researchers created sample sets to address the effects of blood collection tube type, delayed centrifugation of EDTA plasma, centrifugation temperature, aliquots, delayed storage, and freeze-thaw

The results showed that collection tube type resulted in different values for all assessed markers

Taken together, this study constructs a standardized operating procedure for plasma processing to facilitate the introduction of blood-based biomarkers into research and clinical settings

references:

Characterization of pre-analytical sample handling effects on a panel of Alzheimer's disease–related blood-based biomarkers: Results from the Standardization of Alzheimer's Blood Biomarkers (SABB) working group

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