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The decline in cognitive function in old age is one of the most important public health challenges in the coming decades
Immune dysregulation, characterized by chronic and exacerbated glial polarization , contributes to cognitive decline by promoting neurodegeneration (synaptic loss and neuronal death)
immunity
Although animal- and human-based studies have linked increased CSF and plasma levels of MCP-1 to functional and brain structural changes associated with cognitive decline in older adults, previous studies have been mostly cross-sectional, including healthy subjects or People diagnosed with dementia
diagnosis
Therefore, Juan Luis Sanchez‑Sanchez et al.
They included 1097 subjects (mean age = 75.
prevention
Use consecutive MCP-1 and dichotomies (the highest quartile value (MCP-1+)), and Aβ42/40 dichotomies
They found that plasma MCP-1, as a continuous variable, was associated with memory deterioration over the 4-year follow-up, particularly in measures of free and cued delayed recall
Plasma MCP-1 as a continuous variable was associated with memory deterioration during 4 years of follow-up,
MCP-1+ vs CCS (4-year between-group difference: β=-0.
In domain-specific analyses, MCP-1+ was associated with declines in the delayed recall subdomain of FCSRT
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