Allogeneic bone marrow plus peripheral blood stem cell hybrid transplant treatment leukemia

, the PLA GeneralHospitalthe first affiliatedHospitalhematology using allogeneic bone marrow stem cell mixed cell transplantation technology, so that afemale suffering from chronic granulocytic leukemiapatients reborn, donated bone marrow and peripheral blood stem cells is the patient's 55-year-old sisterPatient Wang is 36 years old, a company employee in GansuIn late June last year, feeling weak, thought it was a cold did not care too muchLater the symptoms gradually worsened, the body appeared in many places, to the localhospital, diagnosed as chronic granulocytic leukemiaLocal hospital stouor treatment, blood image gradually returned to normal, but then appeared fever, sore limbs, facial swelling and other symptoms, on November 8 last year, the PLA General Hospital, the first affiliated hospital hematology department for treatmentDirector Wu Xiaoxiong of hematology department made a careful examination of the patient, and comprehensively analyzed the patient's condition and the previous treatment, think that the patient is still in the chronic period, as soon as possible to carry out allogeneic bone marrow transplant is the most promising treatmentAfter examination of the configuration, the hlA site of the patient's elder sister is fully compatible with the patientIn order to ensure the success of the transplant, the general donor is not more than 50 years old, and the elder sister is 55 years old, and both sides have a history of pregnancy, the use of peripheral blood stem cells alone will affect the success of transplantationAfter careful discussion and the consent of the donor, they decided to take a combination of bone marrow stem cell plus peripheral blood stem cell transplant On the basis of pretreatment of patients, on November 26 and 27 last year, the bone marrow stem cells and peripheral hematopoietic stem cells of the elder sister were separated and imported into the patient's body On the 14th day after the transplant, the patient's hematopoietic function began to recover and the patient walked out of the sterile ward on the 17th day In the transplant process granulocyte saloon deficiency period, patients have had bloating, diarrhea and rejection reactions, after active treatment was promptly corrected, recently reviewed, patients are back to normal indicators Director Wu Xiaoxiong said that chronic granulocytic leukemia starts slowly, about 75% to 85% of patients in 1 to 5 years from the stabilization period to the rapid change period Once the rapid change, more than half of the cases die within 3 months, only a few cases can survive more than 1 year, so the key to the treatment of chronic granulocytic leukemia is to prevent the entry of acceleration and rapid change At present, it is recognized at home and abroad that the most effective means of rooting out chronic granulocytic leukemia is allogeneic bone marrow transplantation, in the past 20 years, nearly 2000 patients with chronic granulocytic leukemia in the world have carried out allogeneic bone marrow transplantation, in the early and chronic stage of the transplant effect is more ideal, especially HLA matching siblings bone marrow transplant effect is the best (Zhang Xianghuai)