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AJH: CAR-T cell therapy targeting B-cell maturation antigen is effective in relapsed/refractory multiple myeloma, including cases with poor performance status

 Last Update: 2022-08-12
 Source: Internet
 Author: User

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Multiple myeloma (MM) is a hematopoietic malignancy characterized by clonal proliferation of plasma cel.

After HDS269B infusion (9×10⁶ CAR⁺cells/kg), 17 patients (369%, 11 ECOG 0-2, 6 ECOG 3-4) developed cytokine release syndrome [Grade 1-2: 14 patients ( 257%); Grade 3: 3 patients (12%.

Table: Adverse Events (AEs) in 49 Patients Treated with Anti-bcma CAR-T Cells

Median progression-free survival (PFS) and overall survival (OS) were 10 months (95% CI 3–17) and 29 months (95% CI 10–40), respective.

Figure: Survival of RRMM patients infused with BCMA CAR-T cel.

The study showed that the safety and efficacy of HDS269B were comparable to other CAR-t therapies evaluated in previous tria.

Overall, single-cell sequencing indicated that the therapeutic effect may be related to mTORC1 signali.

Original source:

Du, J ,Wei, R ,Jiang, S , et .

Du, J ,Wei, R ,Jiang, S , et .
CAR-T cell therapy targeting B cell maturation antigen is effective for relapsed/refractory multiple myeloma, including cases with poor performance statu.
Am J Hemato.
2022 ;1 -
doi:11002/a.
2658 Du, J ,Wei, R ,Jiang, S , et .
CAR-T cell therapy targeting B cell maturation antigen is effective for relapsed/refractory multiple myeloma, including cases with poor performance statu.

Am J Hemato.

2022 ; 1- doi:11002/a.

2658 Du, J Wei, R Jiang, S CAR-T cell therapy targeting B cell maturation antigen is effective for relapsed/refractory multiple myeloma, including cases with poor performance status Am J Hematol 2022 1 9in this message

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