Aging: Prognosis value of immunoscoring and immune microenvironment-related genes to hepatocellular carcinoma
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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Mastering the characteristics of tumor immune microenvironment is very important to improve the effect of immunotherapyin this study, researchers calculated immune and matrix scores in 371 patients to quantify immune and matrix cell immersion in the microenvironment of hepatocellular carcinoma (HCC) tumorsThe weighted gene co-expression network analysis and protein-protein interaction network were analyzed to identify genes related to immune microenvironmentresults showed that patients with high immunization scores had a higher rate of recurrence for four yearsTP53, CTNNB1 and AXIN1 mutations varied significantly with immune scoresIn the analysis of modules related to immune scores, the Kyoto Encyclopedia of Gene and Genomic Pathways, as well as the terms of the gene ontology, are closely related to immune processes, tumor occurrence and metastasisTwelve new immune microenvironment-related genes were identified and were significantly positively correlated with seven immune checkpoint genesIn prognosis analysis, 11 genes associated with immune microenvironment showed high expression, 9 of which were validated in the GSE62232 dataset and significantly correlated with good prognosisour findings suggest that calculating immune and matrix scores can help determine tumor purity and immune cell immersion in the microenvironment of tumorsThe nine immune microenvironmental-related genes identified in this study have the potential to serve as a prognosis marker for liver cancer
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