Aging: New Immune-Related Gene Prognosis Biomarkers for Melanoma: Related to Tumor Microenvironment
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Last Update: 2020-05-29
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Source: Internet
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Author: User
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Melanoma is a form of skin cancer that can spread to other organs and is the cause of death in most skin cancer patientsTherefore, the identification of immunobiomarkers for the early diagnosis and treatment of melanoma is imperativegenetic samples of melanoma were retrieved from the TCGA and GEO databases, while immune-related genes (IRg) were retrieved from the ImmPort databaseThe prognosis of melanoma was classified using WGCNA, Cox regression analysis and LASSO analysisTHE ESTIMATE AND CIBERSORT ALGORITHMS ARE USED TO EXPLORE THE RELATIONSHIP BETWEEN RISK SCORES AND TUMOR IMMUNODEFICIENCYThe biological signal ingressstransmission pathway is explored through GSEA analysis63 immune-related genes of the 1,039 unique IRgs retrieved were associated with the overall survival rate of melanomaThe multi-IRG classifiers built with eight IRG demonstrate strong predictive powerCompared with current clinical data, the classification instrument has better predictive powerGSEA analysis shows that there are multiple signal transduction differences between high-risk groups and low-risk groupsIn addition, biomarkers are associated with a variety of immune cells and immuno-immersion in tumor microenvironmentsimmune-related gene prognosis biomarker sits an effective potential prognostic classifier in immunotherapy and monitoring of melanoma
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