Age-related changes in B cell function and differentiation lead to female bias in lupus mouse models

Viruses and self- immune diseases (such as systemic lupus erythematosus ( SLE immune response)) exhibits gender differences
.

Both sex hormones and genes on the X chromosome are related to this gender difference

Viruses and self- immune diseases (such as systemic lupus erythematosus ( an immune SLE immune response)) exhibits gender differences

The study proved that DKO ABCs show gender differences in the following aspects: the number of ABCs characterized by CD11c and T-bet (as shown in the figure above), the up-regulation of interferon-stimulating genes ( ISG ) and effector B cells (germinal center ( GC) ) Differentiation of B cells and plasmablasts ( PB ) / plasma cells ( PC )) .

DKO females show more pronounced GC and PB/PC expansion than DKO males .

The study proved that DKO ABCs show gender differences in the following aspects: the number of ABCs characterized by CD11c and T-bet (as shown in the figure above), the up-regulation of interferon-stimulating genes ( ISG ) and effector B cells (germinal center ( GC) ) Differentiation of B cells and plasmablasts ( PB ) / plasma cells ( PC )) .
DKO females show more pronounced GC and PB/PC expansion than DKO males .
DKO ABCs subjected to clonal expansion and differentiate into oligonucleotides CD11c + and CD11c- effector B cell population, by B -cell receptor ( the BCR ) have proved sequencing and fate profiles two kinds of B cell populations and pathogenic pro-inflammatory functions .
Although from male and femaleDKO 's ABCs show similar BCR profiles, and their significant differences in function and differentiation indicate that they may adopt different molecular procedures

in conclusion:

Conclusion: Conclusion:

Age-related B cells ( ABCs ) have gender differences in function and differentiation, and play an important regulatory role in antiviral responses and autoimmune diseases
.

Age-related B cells ( ABCs ) have gender differences in function and differentiation, and play an important regulatory role in antiviral responses and autoimmune diseases.

 

Source:

Ricker E, Manni M, Flores-Castro D, Jenkins D, Gupta S, Rivera-Correa J, Meng W, Rosenfeld AM, Pannellini T, Bachu M, Chinenov Y, Sculco PK, Jessberger R, Prak ETL, Pernis AB.

Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice.
Nat Commun.

Ricker E, Manni M, Flores-Castro D, Jenkins D, Gupta S, Rivera-Correa J, Meng W, Rosenfeld AM, Pannellini T, Bachu M, Chinenov Y, Sculco PK, Jessberger R, Prak ETL, Pernis AB.
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice.
Nat Commun.
2021 Aug 10;12(1):4813.
doi: 10.
1038/s41467-021-25102-8.
PMID: 34376664; PMCID: PMC8355159.
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