Age&Aging: Subversion!

In medicine, twins provide a unique and valuable source of information to better estimate the relative importance of genetic and environmental influences to various traits and functions
.

However, it is becoming increasingly clear that in most processes related to development, function, and disease, genes can only explain some of the observed differences

In medicine, twins provide a unique and valuable source of information to better estimate the relative importance of genetic and environmental influences to various traits and functions

Monozygous (MZ) twin pairs share the same DNA sequence, but often behave inconsistently, indicating that the same genotype can produce different phenotypes

Cognitive function is an area affected by both genetic and variable environmental risk factors
.

Previous twin studies have agreed that cognitive abilities can also be inherited in old age, but there are differences related to the specific abilities studied

Cognitive function is an area affected by both genetic and variable environmental risk factors

Evidence shows that a healthy life>

However, it is worth noting that these studies often ignore the heterogeneity of cognitive trajectories
.

The question is whether dividing individuals into different subgroups can distinguish the relative contributions of environmental and genetic influences

However, it is worth noting that these studies often ignore the heterogeneity of cognitive trajectories

In this study, the researchers fitted the mixed growth model with the Mini Mental State Test (MMSE) scores of the Swedish OCTO twin study participants , the oldest identical twins and same-sex fraternal twins.
It is to investigate whether twins can be classified into the same category of cognitive changes .

The specific category trajectories observed by the MMSE and predicted by the model are plotted as a function of time

The specific category trajectories observed by the MMSE and predicted by the model are plotted as a function of time

As a result, four different groups were identified, and their MMSE trajectories followed different patterns of change over time :

As a result, four different groups were identified, and their MMSE trajectories followed different patterns of change over time :

1) Better performance and stable group: The older the age, the lower the baseline MMSE value, and the higher the education level, the higher the baseline MMSE score
.

And the same age group, women's cognitive function performance is better than men

1) Better performance and stable group: the older the age, the lower the baseline MMSE value, and the higher the education level, the higher the baseline and education level, the higher the baseline and education level, the higher the baseline MMSE score

2) better performance and slow the deterioration of the group: baseline demented elderly baseline elderly with dementia baseline elderly people with dementia poor performance of MMSE and dementia than those without The elderly are falling faster

3) Mildly impaired and rapidly deteriorating group: people with higher education levels, people with higher

4) Severely damaged and rapidly deteriorating group: It is also observed that individuals with a high level of education decline faster than individuals with a low level of education
.
It is also observed that individuals with a high level of education decline faster than individuals with a low level of education
.
It is also observed that individuals with a high level of education decline faster than individuals with a low level of education
.

Distribution of homozygous and heterozygous individuals across classes

Distribution of homozygous and heterozygous individuals across classes

It is worth noting that the results show that there is no correlation between whether they are homozygous and the above grouping
.

It is worth noting that the results show that there is no correlation between whether they are homozygous and the above grouping
.
It is worth noting that the results show that there is no correlation between whether they are homozygous and the above grouping
.

In summary, this study provides evidence for a more substantial influence of environment rather than genetics on the trajectory of cognitive changes in later life
.

In summary, this study provides evidence for a more substantial influence of environment rather than genetics on the trajectory of cognitive changes in later life
.
In summary, this study provides evidence for a more substantial influence of environment rather than genetics on the trajectory of cognitive changes in later life
.

 

 

references:

references:

Do I lose cognitive function as fast as my twin partner? Analyses based on classes of MMSE trajectories of twins aged 80 and older, Age and Ageing, Volume 50, Issue 3, May 2021, Pages 847–853, https://doi.
org/10.
1093/ageing/afaa239

Do I lose cognitive function as fast as my twin partner? Analyses based on classes of MMSE trajectories of twins aged 80 and older, Age and Ageing, Volume 50, Issue 3, May 2021, Pages 847–853, https://doi.
org/10.
1093/ageing/afaa239 Do I lose cognitive function as fast as my twin partner? Analyses based on classes of MMSE trajectories of twins aged 80 and older, leave a message here