Advances have been made in the study of precision therapy of tumor subcellulars

Recently,
Zhang Pengfei, associate researcher of Cai Lintao's research group at the Shenzhen Institute of Advanced Technology, and Yan Ping, a researcher, collaborated with Zhou Lihua, a full-time teacher at the School of Applied Biology of Shenzhen Institute of Technology, and Huang Wenzhong, a professor at Southern University of Science and Technology, to develop an endogenesis-based targeting of Rodin ming-G2 on the basis of prior work (ACS applied materials and interfaces, 2019).
found that traditional photosensitive agents have the disadvantages of insufficient reactive oxygen production and low targeting ability of subcellular devices. Therefore, the development of new high-efficiency reactive oxygen production and subcellular targeting photosensitive agents to improve the effect of photodynamic therapy, to achieve accurate photodynamic treatment of cancer is of great significance. On the basis of previous studies, the researchers obtained high-efficiency metal complex photosensitive agents by altering metal elements, further constructed ligation control strategies, and enhanced Rodinmin's single-line oxygen production and subcellular targeting capabilities by changing cyclic ligations and regulating photochemical/physical and biological properties.
the study shows that the ligated metal complex (Ir-Rho-G2) shows good subcellular endocytocyte endocellular mesh targeting ability and low dark toxicity; The experimental results of live near-infrared fluorescence imaging and photodynamic therapy of living tumor showed good tumor targeting and significant tumor growth inhibition, respectively. Therefore, the use of lien control strategy to develop high-efficiency reactive oxygen production and cytogenetic targeting ability of photo-diagnosis and photosensitive agent, is conducive to the precise treatment of tumors.
the findings were published online online in The Journal of Chemical. The research work has been supported by the National Natural Science Foundation of China, the Key Laboratory of Nanopharmaceuticals in Guangdong Province, and the Shenzhen Science and Technology Program. (Source: Shenzhen Institute of Advanced Technology)
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