Advances have been made in the construction of microvascular stents

professor
, professor of rectal surgery at the Ninth People's Hospital affiliated with Shanghai Jiaofu University School of Medicine, istemia is a difficult challenge that is often faced in all surgical clinical practices. Corresponding to rectary surgery, the blood supply of flaps is the focus of research. As a common repair method for burns, violent injuries, congenital malformations and scarring, flap transplantation is very demanding for blood transport reconstruction. No matter how the transplant is performed, the fundamental principle is to guarantee the blood transport and survival rate of the flap in the transplant area, otherwise ischemic necrosis of the flap will bring unpredictable secondary physiological and psychological harm to the patient. Three-dimensional vascular stent can guide the new microvascular vessels to blood supply to the flap area, but the previous three-dimensional stent because of its large size, low precision is difficult to meet the actual needs. How to make water gel material with high biocompitiveity but poor printing performance into microvascular stent is a difficult problem in petal transplantation and even in the whole regenerative medicine field.
The team drew on the natural phenomenon of apple peel drying and curling to make tiny hollow tubes (MHTs) in various shapes, such as single-rooted, double-forked, trident and ringed hollow brackets. At the same time, by changing the degree of photorelinking or the concentration of hydrogels, the inner diameter of MHTs (50-500 m) can be adjusted within a certain range. And the principle of self-curling phenomenon is confirmed by scanning electroscope and finite meta mathematical simulation. The microvascular stent is able to load the endothor cells of the blood vessel well and build tiny blood vessels (50-500 m in diameter) with a complete endoskin form outside the body.
, the team tested the effects of microvascular stents using isoemia models of any animal flap. Underneath the junction of the flap and the surrounding normal skin, a bridge is made through a gelatin microvascular stent helps the new blood vessels reach the ischemia of the flap smoothly. It was observed that the necrosis rate of the flaps in the experimental group decreased significantly, and histological analysis results also showed that the degree of blood transport reconstruction at the far end of the flap was higher than that of the control group.
experts said that this kind of self-curlying MHTs can be widely used in the construction of microvascular stents, has a good clinical transformation prospects, can provide the necessary guidance support for vascular regeneration of isoemia tissue.
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