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Actinomycetes (Streptomyces lividans)

 Last Update: 2020-11-21
 Source: Internet
 Author: User

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gram negative antibiotics

agrobacterium tumefaciens

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Agrobacterium tumefaciens
is best known for its ability to transform plants by delivering the T-
DNA
that is processed and transferred from the resident Ti plasmid to the recipient plant cells. Less well known is the capacity of this Gram-negative bacterium to transfer its T-DNA into fungi and actinomycetes. Procedures are described on the use of the promiscuous T-DNA transfer system of
A. tumefaciens
to transform members of the actinomycetes. Integration of the T-DNA derivatives into the
Streptomyces
chromosome provides opportunities of obtaining valuable mutants of this antibiotic producing soil organism.

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