ACS Nano, a top journal in the field of nanomedicine, published the research results of Shao Longquan's team

Recently, the Shao Longquan team of the Stomatological Hospital published a review article
entitled "How Nanoparticles Open the Paracellular Route of Biological Barriers: Mechanisms, Applications, and Prospects" online in ACS Nano, a top journal in the field of nanomedicine.

Biological barriers such as respiratory tract, digestive tract, skin, blood brain, placenta are important lines of defense to protect the human body from pathogenic microorganisms and harmful substances, but they also become the biggest obstacle to
the absorption of hydrophilic macromolecular drugs.
With the development of nanomedicine, the interaction between nanomaterials and biological barriers has attracted more and more attention
.
However, existing studies have focused on how nanomaterials cross biological barriers through the cell-penetrating pathway, and there is a lack of systematic review
of how nanomaterials affect paracellular transport pathways, resulting in toxic or therapeutic effects on target organs.
Based on this, this paper is the first to start from the perspective of nanomaterials opening the cell bypass pathway, and explain the interaction
between nanomaterials and biological barriers.

In this paper, the intrinsic molecular mechanism of nanomaterials affecting the structure and function of key proteins in cellular bypass pathways (mainly tight junctions, adhesion junctions and cytoskeletons) is first discussed, and the nanomaterials are systematically summarized to further regulate cell bypass pathways and open biological barriers
by directly interacting with protein components on cell membranes, by affecting oxidative stress and inflammatory effects.
Secondly, this paper summarizes the factors affecting the ability of nanomaterials to open cell bypass pathways, and proposes a design strategy
for nanomaterials to improve the efficiency of paracellular transport more safely and effectively.
Finally, based on the current status of mechanism research in related fields, the limitations of existing research models and methods and future research directions
are proposed.
Based on a series of analytical discussions on the interaction between NPs and gatekeepers regulating cellular bypass pathways and their molecular mechanisms, this review provides new insights
for nanomaterials to cross various biological barriers to achieve safe, controllable and efficient drug delivery.

Wu Junrong, a postdoctoral fellow at the Stomatological Hospital of Southern Medical University, is the first author of this paper, and Professor Shao Longquan is the corresponding author
.
Taking the biological effects of nanomaterials as the starting point, Professor Shao's research group conducted systematic and in-depth research on the related roles and internal mechanisms of nanomaterials in promoting tissue repair and regeneration, regulating nerve function, and antibacterial, and the research results were published in Adv Funct Mater, ACS Nano, Bioact Mater, Adv Drug Deliver Rev, J Hazard Mater, J Control Release, J Nanobiotechnol, Microbiol Spectr, J Dent Res and other international high-level journals
.