ACS Chem Biol: a powerful stimulant for tumor Sos1
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Last Update: 2019-04-15
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Source: Internet
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Author: User
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April 15, 2019 / biogenic Valley BIOON / - ras protein is responsible for regulating cell growth, survival and proliferation in an activated state However, the uncontrolled activation of Ras almost led to one third of tumors, helping cancer cells to avoid the killing of anti-cancer drugs Therefore, RAS is an important and effective anti-cancer target Photo source: ACS chemical biology Ras protein becomes active through guanine nucleotide exchange (GTF exchange GDP), which is catalyzed by guanine nucleotide exchange factor protein, such as son of selenium homologue 1 (Sos1) Dr Stephen fesik and his colleagues have found in the past that a small group of molecules can bind to Sos1, thus activating the nucleotide exchange of Ras In a recent article published in ACS chemical biology, they reported that these compounds can regulate two downstream signaling pathways through independent cell response They also found a powerful Sos1 stimulant that, compared with other molecules that cause the Miss effect, can quickly trigger the effect of target molecules at very low concentrations The researchers said the discovery would allow them to further determine the targeting efficiency of Sos1 stimulants, thus speeding up their drug development process Reference: Denis T Akan et al Small molecular Sos1 agonists modular MAPK and PI3K signaling via independent cellular responses, ACS Chemical Biology (2019) Doi: 10.1021/accchembio.8b00869
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