Academic News The team of Professor Han Ying of Xuanwu Hospital of Capital Medical University, together with the team of Professor Shuni and Professor Liu Hesheng, found that multicognitive SCD has higher levels of Aβ deposition

The team of Professor Han Ying of the Department of Neurology, Xuanwu Hospital of Capital Medical University, together with the team of Professor Shuni and Professor Liu Hesheng, published a report in the international academic journal Journal of Alzheimer's Disease entitled "Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A.
" Study from the SILCODE", which initially explores the differences
in cortical Aβ deposition between multicognitive SCD and single-memory cognitive domain SCD.

Introduction to the study

Subjective cognitive decline (SCD) is an important risk factor for Alzheimer's disease (AD) and is strongly associated
with cortical Aβ deposition.

The main complaint of the memory cognitive domain is the most common manifestation of the SCD population, but SCD can also affect multiple cognitive domains
such as language, attention, and execution.

The objective of this study was to explore the differences between
single-memory cognitive domain SCD and multi-cognitive domain SCD in cortical Aβ deposition.

The study included 63 SCD participants, all of whom underwent systematic clinical history collection, SCD assessment, neuropsychological scale evaluation, and Aβ-PET scanning
.

The SCD assessment uses the SCD Structured Questionnaire (SCD-I), which evaluates
the SCD for multiple cognitive domains such as memory, language, organization/planning, and attention.

Key findings

1.
In terms of demographics and objective cognitive performance, there was no significant difference
between single-domain SCD and multi-cognitive domain SCD.

2.
Compared with single-memory cognitive domain SCD, multicognitive domain SCD has higher levels of
Aβ deposition in the whole brain and in the left temporal gyrus.

3.
In all samples, Aβ SUVR of the whole brain was found to have a significant negative correlation
with the delayed recall score.

This study preliminarily evaluated the differences between single-domain SCD and multicognitive SCD in cortical Aβ deposition, and found that multicognitive SCD has higher Aβ deposition levels, which may provide a simple screening strategy
for early prevention of AD in high-risk populations.