A team of Chinese and foreign scientists has solved the problem of repairing spinal cord injuries

, Li Xiaoguang, a dual professor at Beijing University of Aeronautics and Astronautics and Capital Medical University, joined forces with the team of Sun Yi of the University of California, Los Angeles, and Tongji Hospital in Shanghai to successfully solve the worldwide medical problem of repairing spinal cord injuries over a period of more than 20 years. The findings were published may 29 in
Paper.
it is understood that spinal cord injury repair is a major international medical problem that has not yet been solved. Spinal cord injury will not only bring great physical and psychological harm to the patient, seriously affect the quality of life of the patient. But as early as 1928, neuroanatomist Sandilands Ramonka asserted that "in the central nervous system of adult mammals, neural pathrapies are to some extent fixed and end-of-life".
ability to regenerate after spinal cord injury in adult animals is extremely limited, even if there is a certain degree of axon regeneration buds, it is difficult to continue to grow through the injured site. The main reason is that the damage to the local micro-environment is not conducive to neural axon regeneration and extension to the target site. Therefore, the key problem to solve the repair of spinal cord injury is how to improve the local micro-environment.
Li Xiaoguang team used self-developed bioactive materials that can release neuronutrients over a long period of time, transplanted them to the site of spinal cord injury, by improving the local micro-environment of the injury, promoting the long-distance growth of the cortical spinal cord bundle and re-entering the host spinal cord tissue across the injury area, which eventually led to the long-term and stable recovery of paralysed lower limb sensation and motor function.
innovation of this achievement lies in the use of simple biomass transplantation, which avoids the body's immune rejection, ethical disputes and the risk of tumors, and opens up new ideas for clinical application.
"This result is important not only because it confirms the role in rodents and non-human primates, but also because the study is based on rich and large samples, which inspires scientists' confidence in the results," said Thomas Judhoff, a tenured professor at Stanford University School of Medicine and a Nobel Laureate in Physiology or Medicine. in
addition, the researchers established a series of non-invasive observational evaluation techniques, such as functional magnetic resonance imaging, magnetic resonance dispersion imaging and pneumotic gait analysis, to assess the efficacy of the results of the study to clinical applications, and laid a solid theoretical and technical foundation. (Source: Science Network Chen Bin)