-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Objective : To characterize the role of interleukin 1 beta (IL-1 beta ) and microvascular endothelial cells (MVEC) in the generation of alternately activated macrophages in the skin and to explore their role in systemic sclerosis (SSc , scleroderma ) Role in the development of skin fibrosis in patien.
OBJECTIVE : To characterize the role of interleukin 1 beta (IL-1 beta ) and microvascular endothelial cells (MVEC) in the generation of alternately activated macrophages in the skin and to investigate their role in systemic sclerosis (SSc , scleroderma ) in the development of skin fibrosis in patien.
Methods : MVECs purified from healthy donor skin and SSc patient skin and prepared conditioned medium were used to generate monocyte-derived macrophage.
Methods Methods : MVECs purified from healthy donor skin and SSc patient skin and prepared conditioned media were used to generate monocyte-derived macrophage.
Results Results : IL-1β- activated MVEC from SSc patients induced monocytes to differentiate into DC-SIGN+ activated macrophages, producing high levels of CCL18 , CCL2 and CXCL8 , but low levels of IL-1
Conclusion Conclusion : The results of this study provide new clues for the vicious cycle involving IL- 1β, MVEC activation and DC-SIGN+ alternate activation of macrophage generation in the development of skin fibrosis in SSc patient.
Source: Laurent,.
, Lapoirie,.
, Leleu,.
, et al (2022), Interleukin-1β–Activated Microvascular Endothelial Cells Promote DC-SIGN–Positive Alternatively Activated Macrophages as a Mechanism of Skin Fibrosis in Systemic Scleros.
Arthritis Rheumatol, 74: 1013-102https://d.
org/11002/a.
42061 Comment here
