A preliminary study on the antidepressant effect of quercetin combined with Hypericum perforatum extract

Recently, researchers from the school of medicine, city college, Zhejiang University published a paper to compare the antidepressant effects of quercetin and hypererin (HF) extracts from Hypericum perforatum in different doses, and explore their synergistic effects It was pointed out that quercetin and Hypericum perforatum extract had synergistic antidepressant effect when they were used in a specific dose proportion This article was published in the Journal of Zhejiang University (Medical Edition), No 06, 2013 Male ICR mice were divided into 9 groups: blank control group, positive control group (paroxetine 10 mg / kg), quercetin group (A: 5 mg / kg, B: 10 mg / kg, C: 20 mg / kg), Hypericum perforatum extract group (HF 10 mg / kg), combined group (a: 2.5 mg / kg quercetin + HF 5 mg / kg; B: 5 mg / kg quercetin + HF 5 mg / kg; C: 10 mg / kg quercetin + HF 5 mg / kg); intragastric administration The effects of reserpine on hypothermia, dyskinesia and hypothermia induced by reserpine were compared in each group (n = 11-12), and the time of immobility was compared in each group (n = 15) There was no significant difference in the effects of reserpine and shortening the tail suspension time between group B and group C (P > 0.05) The effects of reserpine on hypothermia induced by reserpine were significantly (P < 0.01) stronger than those of quercetin B, and the effects of reserpine on shortening the tail suspension time were significantly (P < 0.05) or significantly (P < 0.01) stronger than those of Hypericum perforatum extract (HF 10 mg / kg) or quercetin B.