A number of longevity drug concept stocks are booming. Does mastering NMN mean having a wealth code?

 Recently, NMPA of the State Food and Drug Administration announced the information that NMN (β-nicotinamide mononucleotide) substances can be registered as new raw materials for "cosmetics", which is considered to be a positive signal for the industry
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On March 21, a number of NMN concept stocks ushered in a surge at the opening
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According to the closing data of the day, Erkang Pharmaceuticals rose by 20%, Zhongsheng Pharmaceutical rose by more than 10%, and Kanghui Pharmaceuticals and Xiwang Foods hit their daily limit
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In the past two years, NMN has been an absolute "top-stream ingredient" in the field of anti-aging, and its popularity has remained high
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It has been registered in Europe, America, Japan and other countries and has become popular worldwide
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So what exactly is NMN sacred? The full name of NMN is β-nicotinamide mononucleotide, which is the precursor of NAD+ (Coenzyme I)
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The full name of NAD+ is nicotinamide adenine dinucleotide.
As a coenzyme of thousands of enzymes in the human body, it participates in cellular respiration in the human body and plays a vital role in energy metabolism, immune system, and material metabolism
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Studies have found that the content of NAD+ in the human body will decline with age, and this change is regarded by scientists as a "sign of aging"
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The decline of NAD+ will accelerate human aging, making people physically weak, lack of energy, osteoporosis, and prone to diabetes, gout and other metabolic diseases, heart disease, stroke and other cardiovascular diseases, Parkinson's, Alzheimer's disease and other neurological diseases , thereby affecting people's quality of life
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Therefore, increasing the content of NAD+ in the body is considered to have anti-aging functions
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NMN is an excellent way to supplement NAD+ Further research has shown that direct supplementation of NAD+ does not relieve the symptoms of aging .
Because the NAD+ molecule is large and cannot be absorbed after direct consumption, it is necessary to increase its content by supplementing small molecule precursor substances
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There are five main precursors of NAD+ in human circulation, tryptophan (Trp), niacin (Na), nicotinamide (Nam), nicotinamide ribose (NR), and nicotinamide mononucleotide (NMN).
one more efficient? From the perspective of indirect NAD+ supplementation, tryptophan, niacin, nicotinamide, and NR/NMN are all acceptable, but supplementing NAD+ by supplementing tryptophan, niacin, and nicotinamide has too many conversion links and low efficiency.
problems, and large doses are likely to cause toxic side effects
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Although no adverse reactions were found in NR supplementation, the comparison between NR and NMN found that the effect of NAD+ improvement after NR supplementation was not obvious, while the effect of NMN supplementation was more significant
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NMN is non-toxic, and the process of converting it into NAD+ is more direct and more efficient.
Based on these two advantages, NMN is considered to be the best way to supplement NAD+, and it was once regarded by the market as an "elixir".

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In February 2020, "GeroScience" published the follow-up results of this research.
The team started with gene expression and found that compared with ordinary old mice, old mice injected with NMN had 590 neurovascular-related genes.
The expression of 204 species returned to the level of young mice
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In February 2021, Professor Takeshi Uchiumi, a distinguished scholar at Kyushu University in Japan, discovered that mitochondria regulate a variety of different signaling and metabolic pathways and play an important role in the cell death program
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At the same time, mitochondrial function gradually declines during aging, accompanied by oxidative phosphorylation (OXPHOS) dysfunction and morphological changes
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The researchers found that after NMN intervention, it can repair mitochondrial function, promote autophagy, enhance lysosomal function, and improve the protein homeostasis of the entire body, and at the same time improve mitochondrial dysfunction and protein homeostasis imbalance, two major signs of aging
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The above studies all show that NMN supplementation can effectively reverse the aging process, but the problem to be faced is that the current clinical data on the positive efficacy of NMN are still mostly concentrated in the animal experimental stage.
What effect it will have on the human body still needs to be confirmed by further scientific research data in the future.

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ta-role="title" data-tools="135 Editor" data-id="110898" >Data from iResearch shows that in 2020, the market size of China's NMN ingredient health care products will reach 5.
106 billion yuan, a year-on-year increase of 34.
87%
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Some brokerages predict that NMN products have a large space.
At the current price, the penetration rate of domestic health care products coverage increases by 1%, which is expected to correspond to a market space of 30.
4 billion yuan, and is expected to reach 100 billion yuan in the future.

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However, as early as more than a year ago, the State Administration for Market Regulation issued the "Letter on Investigating the Illegal Operation of "Elixir" (Shijian Shijing (Department) Letter [2021] No.
4), which clearly prohibits NMN in China It is produced and operated as a food, and it is emphasized that at present, NMN has not obtained licenses for medicines, health food, food additives and new food raw materials in China
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The recent approval of NMN substances as new raw materials for "cosmetics" does not mean that "elixirs" have passed the food filing
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This is because food grade raw materials are higher than cosmetic grade raw materials
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Food and cosmetics are subject to different product standards, raw material requirements, and production conditions according to different regulations
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From the perspective of wind direction alone, through the filing of cosmetics, it can only show the country's encouragement of raw material innovation
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As for how far to go from the filing of cosmetic raw materials to the filing of food raw materials, it depends on the situation of basic research
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The eternal pursuit of youth and health makes the topic of anti-aging never out of date, and every breakthrough in scientific research may bring huge market space
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In the popularization and sales of products, one-sided promotion misleads consumers into thinking that as long as NMN is adopted, various age-related aging phenomena can be improved or alleviated, which will lead to health hazards and new health problems
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At present, the research and development of NMN products is more reflected in the word-of-mouth effect, and the future trend of the NMN market still needs time and clinical trials to continuously verify
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References: 1.
Cell metabolism "NAD + Intermediates: The Biology and Therapeutic Potential of NMN and NR.
2.
Yoshino M, Yoshino J, Kayser BD, et al.
Nicotinamide mononucleotide increases muscleinsulin sensitivity in prediabetic women.
Science.
2021 Jun11; 372(6547):1224-1229.
doi: 10.
1126/science.
abe9985.
Epub 2021 Apr 22.
PMID: 33888596; PMCID: PMC8550608.
3.
IgarashiM, Miura M, Nakagawa-Nagahama Y, et al.
Chronicnicotinamide mononucleotide supplementation elevates blood nicotinamide adeninedinucleotide levels and alters muscle motility in healthy old men.
ResearchSquare, 09 Jun 2021.
DOI: 10.
21203/rs.
3.
rs-455083/v1 PPR: PPR354742.
Article source: CPhI Pharmaceutical Online WeChat Official Account