A novel mechanism of autophagy promoting pancreatic cancer proliferation in the tumor microenvironment

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrous connective hyperplasia in which cancer-associated fibroblasts (CAFs) are one of the most critical stromal cells in the tumor microenvironment

Autophagy is a lysosome-dependent protein degradation process that plays an important role in the tumor microenvironment

On July 11, 2022, Professor Zhao Ying's team from Peking University School of Basic Medicine published a research paper titled "Autophagy loss impedes cancer-associated fibroblast activation via downregulating proline biosynthesis" online in the journal Autophagy, discovering cancer-associated fibroblasts Defects in autophagy in fibroblasts impede activation of cancer-associated fibroblasts by inhibiting proline biosynthesis and collagen production

On August 18, 2022, Prof.

CAFs are one of the most critical stromal cells that interact with pancreatic ductal adenocarcinoma (PDAC) and promote tumor growth, metastasis and therapy resistance

The team further found that NUFIP1-dependent autophagy plays a key role in CAFs promoting the growth of PDAC

Interestingly, nucleosides, as a nutrient, are not directly utilized by tumor cells, but induce the consumption of glucose by tumor cells through MYC

The above work has been supported by the key research and development plan of the Ministry of Science and Technology, the general project of the National Natural Science Foundation of China, and the special funding of Peking University Clinical +

Original link:

https://doi.

(Peking University School of Basic Medicine)