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    Home > Biochemistry News > Biotechnology News > A novel mechanism by which circSV2b is involved in the regulation of oxidative stress in Parkinson's disease through the miR-5107-5p-Foxk1-Akt1 axis

    A novel mechanism by which circSV2b is involved in the regulation of oxidative stress in Parkinson's disease through the miR-5107-5p-Foxk1-Akt1 axis

    • Last Update: 2022-08-19
    • Source: Internet
    • Author: User
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    On August 12, 2022, the team of Pro.


    Based on the fact that the diagnosis of PD still mainly depends on the patient's symptoms and the lag of imaging methods, and the misdiagnosis rate is high, the study focused on the exploration of new low-invasive molecular markers that can be used for clinical diagnosis, and analyzed the molecules involved in P.


    The research team conducted RNA sequencing in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, MPTP) induced Thirty-three differentially expressed circRNAs were detected in the PD mouse mode.


    The mechanism of circSV2b involved in MPTP-induced PD (Cheng, .


    PhD student Cheng Quancheng and Professor Wang Jianwei from Peking University School of Basic Medicine are the first authors of the paper, and Professor Zhang Weiguang and Associate Professor Chen Chunhua are the corresponding author.


    Original link: https://do.


    (Peking University School of Basic Medicine)

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