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The accumulation of amyloid in the brain is the first step
In the study, published Aug.
Every once in a while, the brain protein aquaporin 4 is synthesized and has an extra small tail
"We were working on a very unreliable basic science question – 'How are proteins produced?' We noticed the interesting thing that sometimes, the protein synthesis machine would go straight through the stop marker at the end and generate this extra bit
Scientists have known that the cell's protein-making mechanism occasionally doesn't stop where it should stop
Sapkota and Dougherty have created tools to see if long-form hydroporin 4 behaves differently
Sapkota believed that increasing the amount of long-waterporin 4 might increase waste removal, so 2560 compounds
Sapkota and Dougherty collaborated with Alzheimer's disease researchers and co-authors John Cirrito , Ph.
The researchers studied mice that had been genetically modified to have high
"There's a lot of data showing that lowering amyloid levels by 20 to 25 percent stops the buildup of amyloid, at least in mice, and the effects we're seeing are in that range
Sulphaquinoxaline is not safe
Darshan Sapkota, Colin Florian, Brookelyn M Doherty, Kelli M White, Kate M Reardon, Xia Ge, Joel R Garbow, Carla M Yuede, John R Cirrito, Joseph D Dougherty.
