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Researchers have discovered the cause of premature birth, a mystery that has long challenged researche.
Preterm birth is the largest cause of neonatal death and morbidity in the .
The muscle of the outer layer of the uterus is special because it is the only muscle that is not neuroregulated and must remain dormant for 40 weeks despite significant expansion and stretching as the fetus develops into a ba.
Stretching uterine tissue, mimicking what happens during pregnancy, activates Piezo1 channe.
"Piezo1" controls the uterus in a dose-dependent manner, upregulated by the chemical Yoda1 and downregulated by the chemical Dooku When Piezo1 was upregulated, the uterus remained relax.
Professor Ian Buxton of the Myometry Research Group at the University of Nevada said:
"Pregnancy is the most impressive example of prolonged mechanical stress on human muscl.
"There are still no drugs to stop premature birth, which is troubleso.
Tissue samples were assessed for contraction and relaxation, comparing the following gestational periods: nonpregnant, term nonpartum, term labor, term nonpartum, and prete.
Original title:
Novel Identification and Modulation of the Mechanosensitive Piezo1 Channel in Human Myometrium
