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William Stewart Halsted, the father of modern surgery, was not only the first to introduce sterile gloves into the operating room, he also developed the use of silk as a suture material
Now, in testing model systems, researchers have found that the compound benzyloxycyclopentadenosine is a safe and effective pain reliever
A promising new class of non-opioid pain relievers (pain relievers) has been discovered that may have fewer side effects than other effective pain relievers
The study, carried out by the Warwick research team in collaboration with researchers from the Universities of Bern, Cambridge, Coventry, Monash and industrial organisations, was recently published in the journal Nature Communications
In the UK, between one-third and one-half of the population report moderately or severely disabling chronic pain
Many drugs work by activating adaptor molecules called G proteins on the cell surface
Dr Mark J.
Professor Bruno Frenguelli from the School of Life Sciences at the University of Warwick, who was the lead researcher on the study, added: "This is an excellent example of an unexpected discovery by the scientific community
Professor Graham Ladds, from the University of Cambridge, co-principal investigator on the project, said: "Investigating agonist bias in GPCRs is an amazing story
Reference: Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression
