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Image: Study author Jussuf Kaifi, MD, a cancer surgeon at the University of Missouri School of Health Care and an assistant professor of surgery at the University of Missouri School of Medicine
Non-small cell lung cancer (NSCLC) is a devastating disease and the leading cause of cancer death in the United States
The researchers extracted tumor fragments from 10 human NSCLC patients and injected them into immunodeficient mice
"These circulating tumor cells have enhanced metastatic potential, and our model suggests that these clusters of cells are associated with cancer recurrence," said study author Jussuf Kaifi, MD, a cancer surgeon at the University of Michigan Health Care and the University of Michigan.
Kaifi's team also tested these tumor cells for resistance to chemotherapy and found that a protein-coding gene called MYC may be involved in tumor resistance to common chemotherapy
"This mouse model generated from lung cancer patient tumors provides a valuable platform for testing drug susceptibility, potentially in the time window before patients experience incurable relapses,
Another notable finding was that the researchers found that tumors generated in the mouse model differed from the original tumors extracted from human patients
"The discovery of a second protein cell population in mouse models and in patient metastases provides exciting avenues for future studies of circulating tumor cells and metastasis development," Kaifi said
No conflict of interest
