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A new mechanism of lung cancer bone metastasis regulation has been discovered!

 Last Update: 2022-09-07
 Source: Internet
 Author: User

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On August 25, 2022, the international academic journal Journal of Clinical Investigation published online the latest research paper titled "IL20RB mediates tumoral response to osteoclastic niches and promotes bone metastasis of lung cancer" by Hu Guohong's research group from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences

Bone is the most frequently metastatic target organ of solid tumors including breast cancer, lung cancer, and prostate cancer, and bone metastases cause fractures, pain, and even death of patients.

Hu Guohong's research group found in the study that under the stimulation of tumor cells, osteoclasts can secrete the cytokine IL19, thereby promoting the proliferation of lung cancer cells expressing the IL19 receptor IL20RB, leading to the occurrence of bone metastasis

Dr.

Figure legend of lung cancer bone metastases: Tumor cells can secrete GM-CSF, thereby inducing osteoclasts to secrete IL20RB ligand, IL19; IL19 binds to IL20RB on the surface of tumor cells and activates the downstream JAK1-STAT3 signal, thereby Enhanced proliferation of tumor cells in bone

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