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In a new study published in Advanced Materials, a team led by Rutgers University in the United States has developed an intelligent drug delivery system that can reduce inflammation of damaged nerve tissue and help treat spinal cord injuries and other diseases that cause neurological disorders.
the drug delivery system includes a porous biodegradable platform that uses nanobiomes that can be implanted into the body and also protects nerve fibers (axons) that connect nerve cells in damaged nerve tissue.
is usually a major factor in the recovery of diseases and injuries in the central nervous system.
Some regenerative medicine methods show great potential in treating spinal cord injury, traumatic brain injury, Alzheimer's disease, Parkinson's disease, stroke and other neurological disorders, but because they suppress the immune system during treatment, they can lead to side effects and increase the risk of infection.
"Our main goal is to suppress nerve inflammation and restore a healthy microenve environment in areas of neurological disorders," said Kim Lee, co-author of the study and a professor in the Department of Chemistry and Chemical Biology at Rutgers University's School of Art and Science.
we spent four years developing the system and showed great potential for smart drug delivery to better treat neurological disorders."
team's unique drug delivery system consists of ultra-thin nanomaterials, sugar polymers and neuroproteins.
the system releases an anti-inflammatory molecule (methyl-strong pine dragon), which can create a good microenvironment and promote the repair and recovery of tissue after nerve damage.
to improve the treatment of neurological disorders by developing innovative, versatile and reliable nanobiomaterial dosing systems.
the team believes the new system can treat not only damage to the central nervous system, but also other diseases, as inflammation is often associated with a variety of problems, including cardiovascular disease, osteoarthritis, diabetes and cancer.
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