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A new holographic microscope allows scientists to see images of the brain through the skull

 Last Update: 2022-10-02
 Source: Internet
 Author: User

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Photo: An ultra-deep 3D holographic microscope

Image source: Institute of Basic Science

Choi Won-sik, deputy director of the Center for Molecular Spectroscopy and Kinetics at the Institute of Basic Science, Kim Boon Seok, a professor at the Catholic University, and Choi Myung-hwan of Seoul National University, have developed a new type of holographic microscope

*For reference, the thickness and transparency of mouse skulls are similar

In order to take a closer look at the internal characteristics of an organism using light, it is necessary to a) provide sufficient light energy to the sample B) to accurately measure the signal

In a complex structure like living tissue, light experiences multiple scatterings, which causes photons to change direction

Back in 2019, researchers at IBS developed for the first time high-speed time-resolved holographic ^{microscopes3)} that can eliminate multiple scatters while measuring the amplitude and phase

The research team successfully quantitatively analyzed the interaction between light and matter, which allowed them to further refine the previous microscope

Specifically, the researchers devised a method that takes advantage of the fact that even if light is fed from different angles, they have similar reflected waveforms, preferring single-scatter waves

The team demonstrated

Prof Kim Boon Seok and Dr.

Deputy Director CHOI Wonshik said: "For a long time, our center has developed ultra-deep biological imaging techniques

day

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