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A new generation of high-efficiency, low-toxicity tumor-specific IL-12 prodrugs

 Last Update: 2022-01-26
 Source: Internet
 Author: User

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On January 7, 2022, the journal " Science Immunology " published online the collaborative research paper "A tumor-specific pro-IL-12 activates preexisting by Prof.

Interleukin 12 (IL-12) is a heterodimer composed of P35 and P40 subunits and is one of the main cytokines that induce cellular immunity

To extend the half-life of IL-12, the researchers first constructed a recombinant IL-12-Fc fusion protein

Further mechanism studies have found that pro-IL-12 can directly act on killer T cells (CTL) in tumors and promote their secretion of IFNγ to play an anti-tumor effect

Diyuan Xue, Ph.

Article link: https://

(Contributed by Peng Hua Research Group)

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Science Immunology: Peng Hua/Fu Yangxin collaborate to develop a new generation of high-efficiency, low-toxicity tumor-specific IL-12 prodrugs

01-23

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A new generation of high-efficiency, low-toxicity tumor-specific IL-12 prodrugs

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Science Immunology: Peng Hua/Fu Yangxin collaborate to develop a new generation of high-efficiency, low-toxicity tumor-specific IL-12 prodrugs